The guidelines contained in this application are designed to provide extensive and easy-to-read information on the dialysability of medications. Numerous sources of literature have been used to prepare the guidelines. For many drugs, including recently approved drugs, research agents, and drugs available in other countries, no dialysis pharmacokinetic studies have been performed. In some cases, the available data may conflict. The dialysis conditions used in published studies may not reflect current dialysis practice and technology. Variations in dialysis duration, dialysate and blood flow rates, dialysis membranes, and whether peritoneal dialysis is continuous or intermittent will affect drug clearance. These guidelines distinguish between conventional hemodialysis and high permeability (high flow) hemodialysis when such data is available.
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